About the HistoReceptomics Profiler (Beta)

The HistoReceptomics Profiler is a web-based platform developed by GeneCentrix, Inc that aims to alleviate the enduring drug discovery problems of:

  • Polypharmacology
  • In vivo phenotype

Simply put, HR allows for the prediction of unforeseen effects a drug or compound will have in off- or on-target tissues.

The HistoReceptomics platform gives you the ability to view the predicted effects of your drug on a wide range of human tissues in one easy to use display. We believe this type of integrated information is essential for modern drug development, drug design and drug repurposing because it can reveal the full range of possible tissue-specific effects of your drug in the preclinical stage. HistoReceptomics data may help identify viable drug candidates, or it may identify idiosyncratic, tissue-specific, adverse effects that would otherwise potentially derail the drug candidate. At the clinical level, HR enables patient/subject stratification to exclude those with specific tissue dysfunction to maximize the probability of FDA approval.

In addition to the HistoReceptomics software, we offer bespoke consulting and research contracts. Please contact us for software and consulting pricing, as well as all other inquiries.

How does HistoReceptomics work? 

Once you input your chemical structure or gene or tissue/cell target into the HistoReceptomics search function, our platform’s proprietary algorithm will integrate data from relevant gene expression and protein-drug interaction databases, including BioGPS, GTeX, ChEMBL, DrugBank, BindingDB and our own, ever-growing database of docking results that currently includes almost 2,000 drugs docked against 6,500+ proteins with more than 352,000 hits.

Your results will be displayed in a comprehensive, organized, easy-to-read analytical profile of your drug, tissue, or target of interest. Drug search results will include our proprietary HistoReceptomics (HR) score, which ranks the activity of your drug across human tissues by combining the affinity of your drug for a given protein target with the expression level of that target in the tissue. Thus, the HR score is a unique number calculated for each specific target-tissue pair. The top-ranked target-tissue pairs will be displayed in the HistoReceptomics web interface, but a full set of ranked results can be downloaded as a CSV for offline analysis.

How do I use HistoReceptomics?

HistoReceptomics is very user-friendly and easy to operate. There are four types of searches on the HistoReceptomics platform:

  • Compound Search: Input of a drug chemical structure returns the set of tissues (and receptors therein) in which the drug is most likely to have bioactivity. The HistoReceptomics search results provide a rich new compendium of disease and drug-specific information.
  • Target Search: Entering a drug target (gene product) returns the tissue and/or cells in which the drug target is significantly overexpressed in normal tissues. Similar insights to the drug search above can be gained using this search.
  • Tissue Search: Searching by tissue returns the most prominently expressed gene targets in that tissue with a p-value threshold defined by the user.
  • Reverse Target Search: This allows the user to see a list of drugs or drug-like compounds that bind to a target of interest.

For a more detailed explanation of how to use HistoReceptomics, please watch our Demo Video.

Is HistoReceptomics secure?

Yes! After you receive your report, including your HR score, the data is yours to save as you wish. The HistoReceptomics Profiler site uses an SSL connection to our server.

For software and consulting pricing, as well as all other inquiries, please contact us at info@genecentrix.com