About the HistoReceptomics Profiler (Beta)

The HistoReceptomics Profiler is a web-based platform developed by GeneCentrix, Inc that allows for the prediction of unforeseen effects a drug or compound will have, either through off-target or on-target, off-tissue activity.

The HistoReceptomics platform gives you the ability to view the predicted effects of your drug on a wide range of human tissues in one easy to use display. We believe this type of integrated information is essential for modern drug development, drug design and drug repurposing because it can reveal the full range of possible tissue-specific effects of your drug in the preclinical stage — HistoReceptomics data may help identify viable drug candidates, or it may identify idiosyncratic tissue-specific, in vivo adverse effects that would otherwise potentially derail the drug candidate. At the clinical level, HR enables patient/subject stratification to exclude those with specific tissue dysfunction to maximize the probability of FDA approval.

How does HistoReceptomics work?

Once you input your chemical structure or gene target into the HistoReceptomics search function, our platform’s proprietary algorithm will integrate data from all relevant gene expression and protein-drug interaction databases, including ChEMBL, DrugBank, and our own, ever-growing database of docking results that currently includes almost 2,000 drugs docked against 6,500+ proteins with more than 352,000 hits.

Your results will be displayed in a comprehensive, organized, easy-to-read analytical profile of your drug, tissue, or target of interest. Drug search results will include our proprietary HistoReceptomics (HR) score, which ranks the activity of your drug across human tissues by combining the affinity of your drug for a given protein target with the expression level of that target in the tissue. Thus, the HR score is a unique number calculated for each specific target-tissue pair. The top-ranked target-tissue pairs will be displayed in the HistoReceptomics web interface, but a full set of ranked results can be downloaded as a CSV for offline analysis.

How do I use HistoReceptomics?

HistoReceptomics is very user-friendly and easy to operate. There are three types of searches on the HistoReceptomics platform:

  • Compound Search: Input of a drug chemical structure returns the set of tissues (and receptors therein) in which the drug is most likely to have bioactivity. The HistoReceptomics search results provide a rich new compendium of disease and drug-specific information.
  • Target Search: Entering a drug target (gene product) returns the tissue and/or cells in which the drug target is significantly overexpressed in normal tissues. Similar insights to the drug search above can be gained using this search.
  • Tissue Search: Searching by tissue returns the most prominently expressed gene targets in that tissue with a p-value threshold defined by the user.

For a more detailed explanation of how to use HistoReceptomics, please watch our Demo Video. After you purchase a subscription, you will be entitled to a Free Online Onboarding Consultation with the option of an ongoing consultancy package with us to allow you to get even more out of the data.

Is HistoReceptomics secure?

Yes! After you receive your report, including your HR score, the data is yours to save as you wish. The HistoReceptomics Profiler site uses an SSL connection to our server. We do not track specific users searches and any stored data is only used to improve the product and is anonymized.

What does HistoReceptomics cost?

Pricing for the HistoReceptomics Profiler (Beta) currently starts at $299/year for individual users and $599 for organizational licenses (5+ users). This discounted rate will increase so act quickly!

For a limited time, we are also offering a Free Trial for you to try out the platform and discover what important insights HistoReceptomics can expose about your drug or gene today.

For questions, consultations, collaborations and partnership inquiries, please reach out to us at info@genecentrix.com or visit the GeneCentrix website at www.genecentrix.com